Design and Analysis of Clinical Non-Inferiority or Superiority
Trials with Active and Placebo Control
Description
Design and analyze three-arm non-inferiority or superiority trials
which follow a gold-standard design, i.e. trials with an experimental treatment,
an active, and a placebo control. Method for the following distributions are implemented:
Poisson (Mielke and Munk (2009) ), negative binomial (Muetze et al. (2016) ),
normal (Pigeot et al. (2003) ; Hasler et al. (2009) ),
binary (Friede and Kieser (2007) ), nonparametric (Muetze et al. (2017) ),
exponential (Mielke and Munk (2009) ).