TrialSize (version 1.4)

ANOVA.Repeat.Measure: ANOVA with Repeat Measures

Description

The study has multiple assessments in a parallel-group clinical trial. \(\alpha_i\) is the fixed effect for the ith treatment \(\sum \alpha_i =0\).

Ho: \(\alpha_{i} = \alpha_{i'} \)

Ha: not equal

Usage

ANOVA.Repeat.Measure(alpha, beta, sigma, delta, m)

Arguments

alpha

significance level

beta

power = 1-beta

sigma

sigma^2 is the sum of the variance components.

delta

a clinically meaningful difference

m

Bonferroni adjustment for alpha, totally m pairs comparison.

References

Chow SC, Shao J, Wang H. Sample Size Calculation in Clinical Research. New York: Marcel Dekker, 2003

Examples

# NOT RUN {
Example.15.3.4<-ANOVA.Repeat.Measure(0.05,0.2,1.25,1.5,3)
Example.15.3.4
# 15
# }