TrialSize (version 1.4)

R Functions for Chapter 3,4,6,7,9,10,11,12,14,15 of Sample Size Calculation in Clinical Research

Description

Functions and Examples in Sample Size Calculation in Clinical Research.

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Install

install.packages('TrialSize')

Monthly Downloads

929

Version

1.4

License

GPL (>= 2.15.1)

Maintainer

Vicky Wu

Last Published

July 6th, 2020

Functions in TrialSize (1.4)

Carry.Over

Test the Carry-over effect

Cox.NIS

Test for non-inferiority/superiority in Cox PH model.

Cox.Equality

Test for equality in Cox PH model.

AB.withDescalation

A + B Escalation Design with Dose De-escalation

ABE

Average Bioequivalence

CrossOver.ISV.Equality

Test for Equality of Intra-Subject Variabilities in Crossover Design

Cox.Equivalence

Test for Equivalence in Cox PH model.

Cochran.Armitage.Trend

Cochran-Armitage's Test for Trend

ANOVA.Repeat.Measure

ANOVA with Repeat Measures

AB.withoutDescalation

A + B Escalation Design without Dose De-escalation

IBE

Individual Bioequivalence

ISCV.Equivalence

Test for Equivalence of Intra-Subject CVs

InterSV.Equality

Test for Equality of Inter-Subject Variabilities

ISV.NIS

Test for Non-Inferiority/Superiority of Intra-Subject Variabilities

Dose.Min.Effect

Williams' Test for Minimum effective dose (MED)

Dose.Response.Linear

Linear Contrast Test for Dose Response Study

MeanWilliamsDesign.Equality

Test for Equality in Multiple-Sample William Design

MeanWilliamsDesign.Equivalence

Test for Equivalence in Multiple-Sample William Design

OneSampleProportion.NIS

One sample proportion test for Non-inferiority/Superiority

ISCV.NIS

Test for Non-Inferiority/Superiority of Intra-Subject CVs

Dose.Response.binary

Linear Contrast Test for Binary Dose Response Study

MeanWilliamsDesign.NIS

Test for Non-Inferiority/Superiority in Multiple-Sample William Design

CrossOver.ISV.Equivalence

Test for Similarity of Intra-Subject Variabilities in Crossover Design

RelativeRisk.Equivalence

Relative Risk in Parallel Design test for Equivalence

Propensity.Score.nostrata

Propensity Score ignoring strata

TwoSampleProportion.Equality

Two sample proportion test for equality

Propensity.Score.strata

Propensity Score with Stratas

OneSide.fixEffect

One-Sided Tests with fixed effect sizes

TwoSampleProportion.Equivalence

Two sample proportion test for equivalence

RelativeRisk.NIS

Relative Risk in Parallel Design test for Non-inferiority/Superiority

CrossOver.ISV.NIS

Test for Non-Inferiority/Superiority of Intra-Subject Variabilitie in Crossover Design

OneSampleProportion.Equality

One sample proportion test for equality

OneSampleProportion.Equivalence

One sample proportion test for equivalence

OneWayANOVA.pairwise

Pairwise Comparison for Multiple-Sample One-Way ANOVA

Nonpara.Two.Sample

Two sample location problem for Nonparametric

InterSV.NIS

Test for Equality of Inter-Subject Variabilities

OneSampleMean.Equality

One Sample Mean Test for Equality

McNemar.Test

McNemar Test in 2 by 2 table

Dose.Response.time.to.event

Linear Contrast Test for Time-to-Event Endpoint in dose response study

QT.parallel

Parallel Group Design in QT/QTc Studies without covariates

TwoSampleProportion.NIS

Two sample proportion test for Non-Inferiority/Superiority

RelativeRisk.Equality

Relative Risk in Parallel Design test for Equality

PBE

Population Bioequivalence

RelativeRiskCrossOver.Equality

Relative Risk in Crossover Design test for Equality

OneSampleMean.Equivalence

One Sample Mean Test for Equivalence

OneSampleMean.NIS

One Sample Mean Test for Non-Inferiority/Superiority

Multiple.Testing

Multiple Testing procedures

TwoSampleSeqCrossOver.Equivalence

Two sample proportion Crossover design test for equivalence

TwoSampleCrossOver.NIS

Two Sample Crossover Design Test for Non-Inferiority/Superiority

RelativeRiskCrossOver.Equivalence

Relative Risk in Crossover Design test for Equivalence

TwoSampleMean.Equality

Two Sample Mean Test for Equality

QOL

Quality of life

QT.PK.crossover

Crossover Design in QT/QTc Studies with PK response as covariate

ISCV.Equality

Test for Equality of Intra-Subject CVs

TwoSampleSurvival.Conditional

Test for two sample conditional data in exponential model for survival data

QT.PK.parallel

Parallel Group Design in QT/QTc Studies with PK response as covariate

ISV.Equality

Test for Equality of Intra-Subject Variabilities

Vaccine.RDI

Reduction in Disease Incidence(RDI) for Vaccine clinical trials.

TwoSampleSeqCrossOver.NIS

Two sample proportion Crossover design for Non-inferiority/Superiority

Vitro.BE

In Vitro Bioequivalence

ISV.Equivalence

Test for Similarity of Intra-Subject Variabilities

Nonpara.Independ

Test for independence for nonparametric study

TwoSampleSeqCrossOver.Equality

Two sample proportion Crossover design test for equality

TwoSampleSurvival.Equality

Test for two sample equality in exponential model for survival data

TwoSampleSurvival.Equivalence

Test for two sample equivalence in exponential model for survival data

TwoSampleMean.Equivalence

Two Sample Mean Test for Equivalence

Stuart.Maxwell.Test

Stuart-Maxwell Test

TrialSize-package

Sample Size calculation in Clinical Research

QT.crossover

Crossover Design in QT/QTc Studies without covariates

Nonpara.One.Sample

One Sample Location problem in Nonparametric

RelativeRiskCrossOver.NIS

Relative Risk in Crossover Design test for Non-inferiority/Superiority

OneSide.varyEffect

One-Sided Tests with varying effect sizes

Sensitivity.Index

Calculate the power for Sensitivity Index

OneWayANOVA.PairwiseComparison

One-way ANOVA pairwise comparison

TwoSampleSurvival.NIS

Test for two sample Non-Inferiority/Superiority in exponential model for survival data

gof.Pearson

Test Goodness of Fit by Pearson's Test

WilliamsDesign.NIS

Williams Design test for Non-inferiority/Superiority

TwoSampleCrossOver.Equality

Two Sample Crossover Design Test for Equality

TwoSide.varyEffect

Two-Sided Tests with varying effect sizes

TwoSampleCrossOver.Equivalence

Two Sample Crossover Design Test for Equivalence

gof.Pearson.twoway

Test Goodness of Fit by Pearson's Test for two-way table

TwoSide.fixEffect

Two-Sided Tests with fixed effect sizes

TwoSampleMean.NIS

Two Sample Mean Test for Non-Inferiority/Superiority

Vaccine.CEM

Composite Efficacy Measure(CEM) for Vaccine clinical trials.

WilliamsDesign.Equality

William Design test for equality

Vaccine.ELDI

The evaluation of vaccine efficacy with Extremely Low Disease Incidence(ELDI)

WilliamsDesign.Equivalence

Williams Design test for equivalence