TrialSize (version 1.4)

Cox.Equivalence: Test for Equivalence in Cox PH model.

Description

b is the log hazard ratio for treatment, delta is the margin

Ho: |b| \( \ge \delta \)

Ha: |b| < \(\delta\)

Usage

Cox.Equivalence(alpha, beta, loghr, p1, d, delta)

Arguments

alpha

significance level

beta

power = 1-beta

loghr

log hazard ratio=log(lamda2/lamda1)=b

p1

the proportion of patients in treatment 1 group

d

the probability of observing an event

delta

delta is the true difference of log hazard rates between control group lamda1 and a test drug group lamda2

References

Chow SC, Shao J, Wang H. Sample Size Calculation in Clinical Research. New York: Marcel Dekker, 2003

Examples

# NOT RUN {
Example.7.3.4<-Cox.Equivalence(0.05,0.2,log(2),0.5,0.8,0.5)
Example.7.3.4


# }