H0: within-subject variance of treatment T is equal to within-subject variance of treatment R
Ha: not equal
The test is finding whether two drug products have the same intra-subject variability in crossover design
CrossOver.ISV.Equality(alpha, beta, sigma1, sigma2, m)significance level
power = 1-beta
within-subject variance of treatment 1
within-subject variance of treatment 2
for each subject, there are m replicates.
Chow SC, Shao J, Wang H. Sample Size Calculation in Clinical Research. New York: Marcel Dekker, 2003