TrialSize (version 1.4)

ISCV.Equality: Test for Equality of Intra-Subject CVs

Description

H0: CVr = CVt

Ha: not equal

The test is finding whether two drug products have the same intra-subject CVs

Usage

ISCV.Equality(alpha, beta, CVt, CVr, m)

Arguments

alpha

significance level

beta

power = 1-beta

CVt

Coefficient Of Variation for treatment T

CVr

Coefficient Of Variation for treatment R

m

for each subject, there are m replicates.

References

Chow SC, Shao J, Wang H. Sample Size Calculation in Clinical Research. New York: Marcel Dekker, 2003