Compare more than two treatment under a crossover design.
H0: |margin| \(\ge \delta \) Ha: |margin| < \( \delta \)
This test is whether the test drug is equivalent to the control in average if the null hypothesis is rejected at significant level alpha
MeanWilliamsDesign.Equivalence(alpha, beta, sigma, k, delta, margin)significance level
power = 1-beta
standard deviation
Total k treatments in the design
the superiority or non-inferiority margin
\(margin=\mu_i-\mu_j\) the difference between the true mean response of group i \(\mu_i\) and group j \(\mu_j\)
Chow SC, Shao J, Wang H. Sample Size Calculation in Clinical Research. New York: Marcel Dekker, 2003