TrialSize (version 1.4)

TwoSampleSeqCrossOver.NIS: Two sample proportion Crossover design for Non-inferiority/Superiority

Description

H0: p2-p1 <= margin

Ha: p2-p1 > margin

Usage

TwoSampleSeqCrossOver.NIS(alpha, beta, sigma, sequence, delta, margin)

Arguments

alpha

significance level

beta

power = 1-beta

sigma

standard deviation in crossover design

sequence

total sequence number

delta

the superiority or non-inferiority margin

margin

margin=p2-p1

References

Chow SC, Shao J, Wang H. Sample Size Calculation in Clinical Research. New York: Marcel Dekker, 2003

Examples

# NOT RUN {
Example.4.3.4<-TwoSampleSeqCrossOver.NIS(0.05,0.2,0.25,2,0,-0.2)
Example.4.3.4
# }