TrialSize (version 1.4)

TwoSampleSurvival.Equivalence: Test for two sample equivalence in exponential model for survival data

Description

margin=lamda1-lamda2, the true difference of hazard rates between control group lamda1 and a test drug group lamda2

H0: |margin| >= delta

Ha: |margin| < delta

This test is whether the test drug is equivalent to the control in average if the null hypothesis is rejected at significant level alpha

Usage

TwoSampleSurvival.Equivalence(alpha, beta, lam1, lam2, k, ttotal, taccrual, gamma, margin)

Arguments

alpha

significance level

beta

power = 1-beta

lam1

the hazard rates of control group

lam2

the hazard rates of a test drug

k

k=n1/n2 sample size ratio

ttotal

Total trial time

taccrual

accrual time period

gamma

parameter for exponential distribution. Assume Uniform patient entry if gamma =0

margin

margin=lamda1-lamda2, the true difference of hazard rates between control group lamda1 and a test drug group lamda2

References

Chow SC, Shao J, Wang H. Sample Size Calculation in Clinical Research. New York: Marcel Dekker, 2003

Examples

# NOT RUN {
Example.7.2.4<-TwoSampleSurvival.Equivalence(0.05,0.2,1,1,1,3,1,0.00001,0.5)
Example.7.2.4

# }