TrialSize (version 1.4)

Vaccine.CEM: Composite Efficacy Measure(CEM) for Vaccine clinical trials.

Description

Let sij be the severity score associated with the jth case in the ith treatment group. \(\mu_i=mean(s_{ij})\), \(\sigma^2_i=var(s_{ij})\).

H0: pT=pC and muT=muC

Ha: pT is not equal to pC and muT is not equal to muC

Usage

Vaccine.CEM(alpha, beta, mu_t, mu_c, sigma_t, sigma_c, pt, pc)

Arguments

alpha

significance level

beta

power=1-beta

mu_t

mean of treatment group

mu_c

mean of control group

sigma_t

standard deviation of treatment group

sigma_c

standard deviation of control group

pt

the true disease incidence rates of the nt vaccines

pc

the true disease incidence rates of the nc controls

References

Chow SC, Shao J, Wang H. Sample Size Calculation in Clinical Research. New York: Marcel Dekker, 2003

Examples

# NOT RUN {
Example.15.6.4<-Vaccine.CEM(0.05,0.2,0.2,0.3,sqrt(0.15),sqrt(0.15),0.1,0.2)
Example.15.6.4


# }