UnifiedDoseFinding (version 0.1.10)

get_oc_Ivanova_binary: Generate operating characteristics for finding the maximum tolerated dose (MTD) of binary endpoint using design by Ivanova et al (2009)

Description

Obtain the operating characteristics of the dose-finding design of binary endpoint by Ivanova et al (2009)

Usage

get_oc_Ivanova_binary(target, eps = 1, truetox, ncohort, cohortsize,
                      n.earlystop = 100, ntrial, startdose = 1,
                      seed = 100)

Value

get_oc_Ivanova_binary() returns the operating characteristics of Ivanova design as a list object, including: (1) selection percentage at each dose level (2) patients treated at each dose level

Arguments

target

the target toxicity rate

eps

the decision criterion. The default value is eps = 1

truetox

a vector containing the true toxicity probabilities of the investigational dose levels

ncohort

the number of cohorts

cohortsize

the cohort size

n.earlystop

the early stopping parameter. The default value is n.earlystop = 100

ntrial

the number of trials

startdose

the starting dose level. The default value is startdose = 1

seed

the seed. The default value is seed = 100

Author

Chia-Wei Hsu, Haitao Pan, Rongji Mu

References

Ivanova, Anastasia, and Se Hee Kim. "Dose finding for continuous and ordinal outcomes with a monotone objective function: a unified approach." Biometrics 65, no. 1 (2009): 307-315.

Examples

target <- 0.3
truetox <- c(0.30, 0.45, 0.50, 0.55, 0.60, 0.65)
ncohort <- 10
cohortsize <- 3
ntrial <- 4000
get_oc_Ivanova_binary(target = target, truetox = truetox, ncohort = ncohort,
                      cohortsize = cohortsize, ntrial = ntrial)