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WGCNA (version 0.95)

Weighted Gene Co-Expression Network Analysis

Description

Functions necessary to perform Weighted Gene Co-Expression Network Analysis

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Version

Install

install.packages('WGCNA')

Monthly Downloads

13,041

Version

0.95

License

GPL (>= 2)

Maintainer

Peter Langfelder

Last Published

September 17th, 2010

Functions in WGCNA (0.95)

automaticNetworkScreening

One-step automatic network gene screening
exportNetworkToCytoscape

Export network to Cytoscape
checkSets

Check structure and retrieve sizes of a group of datasets.
sigmoidAdjacencyFunction

Sigmoid-type adacency function.
TOMplot

Graphical representation of the Topological Overlap Matrix
intramodularConnectivity

Calculation of intramodular connectivity
corPredictionSuccess

Qunatification of success of gene screening
moduleNumber

Fixed-height cut of a dendrogram.
hubGeneSignificance

Hubgene significance
mergeCloseModules

Merge close modules in gene expression data
adjacency

Calculate network adjacency
TOMsimilarity

Topological overlap matrix similarity and dissimilarity
addGrid

Add grid lines to an existing plot.
networkConcepts

Calculations of network concepts
WGCNA-package

Weighted Gene Co-Expression Network Analysis
addTraitToMEs

Add trait information to multi-set module eigengene structure
cutreeStaticColor

Constant height tree cut using color labels
overlapTable

Calculate overlap of modules
fixDataStructure

Put single-set data into a form useful for multiset calculations.
multiSetMEs

Calculate module eigengenes.
pickSoftThreshold

Analysis of scale free topology for soft-thresholding
consensusOrderMEs

Put close eigenvectors next to each other in several sets.
orderMEs

Put close eigenvectors next to each other
recutConsensusTrees

Repeat blockwise consensus module detection from pre-calculated data
addGuideLines

Add vertical ``guide lines'' to a dendrogram plot
greenBlackRed

Green-black-red color sequence
cor

Fast calculations of Pearson correlation.
corPvalueFisher

Fisher's asymptotic p-value for correlation
plot.mat

Red and Green Color Image of Data Matrix
checkAdjMat

Check adjacency matrix
blockwiseModules

Automatic network construction and module detection
networkScreeningGS

Network gene screening with an external gene significance measure
rgcolors.func

Red and Green Color Specification
relativeCorPredictionSuccess

Compare prediction success
exportNetworkToVisANT

Export network data in format readable by VisANT
alignExpr

Align expression data with given vector
nPresent

Number of present data entries.
moduleEigengenes

Calculate module eigengenes.
goodGenes

Filter genes with too many missing entries
conformityBasedNetworkConcepts

Calculation of conformity-based network concepts.
bicorAndPvalue

Calculation of biweight midcorrelations and associated p-values
labels2colors

Convert numerical labels to colors.
redWhiteGreen

Red-white-green color sequence
softConnectivity

Calculates connectivity of a weighted network.
moduleColor.getMEprefix

Get the prefix used to label module eigengenes.
collapseRows

Select one representative row per group
addErrorBars

Add error bars to a barplot.
AUV2predicted

Prediction of Weighted Mutual Information Adjacency Matrix by Correlation
labelPoints

Label scatterplot points
simulateMultiExpr

Simulate multi-set expression data
sizeGrWindow

Opens a graphics window with specified dimensions
stat.bwss

Between and Within Group Sum of Squares Calculation
signumAdjacencyFunction

Hard-thresholding adjacency function
plotClusterTreeSamples

Annotated clustering dendrogram of microarray samples
Inline display of progress

Inline display of progress
simulateEigengeneNetwork

Simulate eigengene network from a causal model
consensusMEDissimilarity

Consensus dissimilarity of module eigengenes.
spaste

Space-less paste
goodSamplesMS

Filter samples with too many missing entries across multiple data sets
correlationPreservation

Preservation of eigengene correlations
goodGenesMS

Filter genes with too many missing entries across multiple sets
GOenrichmentAnalysis

Calculation of GO enrichment (experimental)
metaZfunction

Meta-analysis Z statistic
removeGreyME

Removes the grey eigengene from a given collection of eigengenes.
verboseBoxplot

Boxplot annotated by a Kruskal-Wallis p-value
cutreeStatic

Constant-height tree cut
randIndex

Rand index of two partitions
bicor

Biweight Midcorrelation
simulateSmallLayer

Simulate small modules
unsignedAdjacency

Calculation of unsigned adjacency
clusterCoef

Clustering coefficient calculation
simulateDatExpr5Modules

Simplified simulation of expression data
fundamentalNetworkConcepts

Calculation of fundamental network concepts from an adjacency matrix.
GTOMdist

Generalized Topological Overlap Measure
corAndPvalue

Calculation of correlations and associated p-values
automaticNetworkScreeningGS

One-step automatic network gene screening with external gene significance
plotNetworkHeatmap

Network heatmap plot
standardScreeningBinaryTrait

Standard screening for binatry traits
displayColors

Show colors used to label modules
TOMsimilarityFromExpr

Topological overlap matrix
mutualInfoAdjacency

Calculate weighted adjacency matrices based on mutual information
dynamicMergeCut

Threshold for module merging
matchLabels

Relabel module labels to best match the given reference labels
simulateDatExpr

Simulation of expression data
blockwiseConsensusModules

Find consensus modules across several datasets.
simulateModule

Simulate a gene co-expression module
stdErr

Standard error of the mean of a given vector.
nearestNeighborConnectivity

Connectivity to a constant number of nearest neighbors
goodSamples

Filter samples with too many missing entries
labeledBarplot

Barplot with text or color labels.
networkScreening

Identification of genes related to a trait
consensusProjectiveKMeans

Consensus projective K-means (pre-)clustering of expression data
colQuantileC

Fast colunm-wise quantile of a matrix.
corPvalueStudent

Student asymptotic p-value for correlation
plotMEpairs

Pairwise scatterplots of eigengenes
nearestNeighborConnectivityMS

Connectivity to a constant number of nearest neighbors across multiple data sets
labeledHeatmap

Produce a labeled heatmap plot
goodSamplesGenesMS

Iterative filtering of samples and genes with too many missing entries across multiple data sets
goodSamplesGenes

Iterative filtering of samples and genes with too many missing entries
vectorizeMatrix

Turn a matrix into a vector of non-redundant components
plot.cor

Red and Green Color Image of Correlation Matrix
plotModuleSignificance

Barplot of module significance
plotDendroAndColors

Dendrogram plot with color annotation of objects
plotColorUnderTree

Plot color rows under a dendrogram
propVarExplained

Proportion of variance explained by eigengenes.
signedKME

Signed eigengene-based connectivity
standardColors

Colors this library uses for labeling modules.
normalizeLabels

Transform numerical labels into normal order.
subsetTOM

Topological overlap for a subset of a whole set of genes
projectiveKMeans

Projective K-means (pre-)clustering of expression data
rankPvalue

Estimate the p-value for ranking consistently high (or low) on multiple lists
recutBlockwiseTrees

Repeat blockwise module detection from pre-calculated data
verboseScatterplot

Scatterplot annotated by regression line and p-value
setCorrelationPreservation

Summary correlation preservation measure
standardScreeningCensoredTime

Standard Screening with regard to a Censored Time Variable
scaleFreePlot

Visual check of scale-free topology
vectorTOM

Topological overlap for a subset of the whole set of genes
preservationNetworkConnectivity

Network preservation calculations
na

Basic Statistical Functions for Handling Missing Values
pickHardThreshold

Analysis of scale free topology for hard-thresholding.
numbers2colors

Color representation for a numeric variable
plotEigengeneNetworks

Eigengene network plot
keepCommonProbes

Keep probes that are shared among given data sets
stat.diag.da

Diagonal Discriminant Analysis
scaleFreeFitIndex

Calculation of fitting statistics for evaluating scale free topology fit.
verboseBarplot

Barplot with error bars, annotated by Kruskal-Wallis or ANOVA p-value
modulePreservation

Calculation of module preservation statistics
greenWhiteRed

Green-white-red color sequence
standardScreeningNumericTrait

Standard screening for numeric traits
collectGarbage

Iterative garbage collection.