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aSPU (version 1.36)

Adaptive Sum of Powered Score Test

Description

R codes for the (adaptive) Sum of Powered Score ('SPU' and 'aSPU') tests, inverse variance weighted Sum of Powered score ('SPUw' and 'aSPUw') tests and gene-based and some pathway based association tests (Pathway based Sum of Powered Score tests ('SPUpath') and adaptive 'SPUpath' ('aSPUpath') test, Gene-based Association Test that uses an extended Simes procedure ('GATES'), Hybrid Set-based Test ('HYST'), extended version of 'GATES' test for pathway-based association testing ('Gates-Simes'). ). The tests can be used with genetic and other data sets with covariates. The response variable is binary or quantitative.

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Install

install.packages('aSPU')

Monthly Downloads

398

Version

1.36

License

GPL-3

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Maintainer

IlYoup Kwak

Last Published

July 28th, 2015

Functions in aSPU (1.36)

aSPUpath

Pathway based Sum of Powered Score tests (SPUpath) and adaptive SPUpath (aSPUpath) test.
aSPUMpath

Pathway based Sum of Powered Score tests (SPUpath) and adaptive SPUpath (aSPUpath) test for meta-analyzed data.
GatesSimes

GATES-Simes test for pathway-based association testing
getlogitp

Get the p-values of the multiple SNPs based on the Wald test in a logistic regresion model.
kegg9

A subset of coronary artery disease (CAD) data
aSPUM

Sum of Powered Score (SPU) tests and adaptive SPU (aSPU) test for meta-analyzed data.
simPathAR1Snp

Simulating a pathway with multiple SNPs.
aSPUpathSingle

Single-gene based version of the Sum of Powered Score tests (SPUpathSingle) and adaptive SPUpathSingle (aSPUpathSingle) test.
aSPU

Sum of Powered Score (SPU) tests and adaptive SPU (aSPU) test.
Hyst

HYST (Hybrid Set-based Test)
exdat

An example data set
GATES2

Gene-based Association Test that uses an extended Simes procedure (GATES)
aSPUw

Inverse variance weighted Sum of Powered Score tests (SPUw) and adaptive SPUw (aSPUw) test.