ANalysis Of Translational Activity (ANOTA).
Description
Genome wide studies of translational control is emerging
as a tool to study verious biological conditions. The output
from such analysis is both the mRNA level (e.g. cytosolic mRNA
level) and the levl of mRNA actively involved in translation
(the actively translating mRNA level) for each mRNA. The
standard analysis of such data strives towards identifying
differential translational between two or more sample classes -
i.e. differences in actively translated mRNA levels that are
independent of underlying differences in cytosolic mRNA levels.
This package allows for such analysis using partial variances
and the random variance model. As 10s of thousands of mRNAs are
analyzed in parallell the library performs a number of tests to
assure that the data set is suitable for such analysis.