apComplex (version 2.38.0)

LCjoin: Computes change in LxC measure

Description

Computes the change in the P=LxC measure for AP-MS protein data when two protein complex estimates are combined into one complex.

Value

The numeric value of the change in P=LxC when two complexes are combined.

Details

These functions are used to evaluate changes in the penalized likelihood when two complexes are combined. They are not meant to be directly used.

References

Scholtens D and Gentleman R. Making sense of high-throughput protein-protein interaction data. Statistical Applications in Genetics and Molecular Biology 3, Article 39 (2004).

Scholtens D, Vidal M, and Gentleman R. Local modeling of global interactome networks. Bioinformatics 21, 3548-3557 (2005).

See Also

bhmaxSubgraph,mergeComplexes,findComplexes

Examples

data(apEX)
PCMG0 <- bhmaxSubgraph(apEX)
PCMG1 <- mergeComplexes(PCMG0,apEX,sensitivity=.7,specificity=.75)