modify

0th

Percentile

Modify binary sequential boundary

Modify several different aspects of a binary sequential boundary. Most modifications do not change the stopping boundaries. The exceptions are 'missN', which allows modifications for missing assessments, and 'closeout', which allows for early stopping of the trial for administrative reasons (i.e., reasons that do not depend on the responses in the trial). Other modifications possible: level of the confidence intervals (using tsalpha, conf.level, or alternative), which boundaries are binding (i.e., can change from a boundary with binding futility boundaries to one with non-binding futility boundaries), null hypothesis value (theta0), and whether the confidence intervals should match the non-binding futility p-values on the superiority boundaries (cipMatch).

Keywords
htest
Usage
modify(b, missN = NULL, theta0 = NULL, tsalpha = NULL, conf.level = NULL, alternative = NULL, cipMatch = TRUE, binding = NULL, closeout=NULL, ...)
Arguments
b
an object of class boundEst
missN
a vector of missed assessments
theta0
null hypothesis probability of success
tsalpha
vector of length 2 with nominal significance level, if not NULL overrides conf.level and alternative
conf.level
confidence level, ignored if tsalpha is not NULL
alternative
character, alternative hypothesis, either 'less', 'greater' or 'two.sided'
cipMatch
logical, for non-binding futility boundaries, should CI match the p-values on the binding boundary
binding
character, which sides are binding: 'both', 'upper', or 'lower'
closeout
total number of trials at early closeout
...
other parameters passed
Value

boundEst

Aliases
  • modify
Examples
b<-designOBF(50)
bmod<-modify(b,missN=30:36)
par(mfrow=c(2,1))
plot(b)
plot(bmod)
Documentation reproduced from package binseqtest, version 1.0.3, License: GPL-3

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