# asat

From coin v1.3-1
by Torsten Hothorn

##### Toxicological Study on Female Wistar Rats

Measurements of the liver enzyme aspartate aminotransferase (ASAT) for a new compound and a control group of 34 female Wistar rats.

- Keywords
- datasets

##### Usage

`asat`

##### Details

The aim of this toxicological study is the proof of safety for the new compound. The data were originally given in Hothorn (1992) and later reproduced by Hauschke, Kieser and Hothorn (1999).

##### Format

A data frame with 34 observations on 2 variables.

`asat`

ASAT values.

`group`

a factor with levels

`"Compound"`

and`"Control"`

.

##### References

Pfl<U+00FC>ger, R. and Hothorn, T. (2002). Assessing equivalence
tests with respect to their expected \(p\)-value. *Biometrical
Journal* **44**(8), 1015--1027. 10.1002/bimj.200290001

##### Examples

```
# NOT RUN {
## Proof-of-safety based on ratio of medians (Pflueger and Hothorn, 2002)
## One-sided exact Wilcoxon-Mann-Whitney test
wt <- wilcox_test(I(log(asat)) ~ group, data = asat,
distribution = "exact", alternative = "less",
conf.int = TRUE)
## One-sided confidence set
## Note: Safety cannot be concluded since the effect of the compound
## exceeds 20 % of the control median
exp(confint(wt)$conf.int)
# }
```

*Documentation reproduced from package coin, version 1.3-1, License: GPL-2*

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