asat

0th

Percentile

Toxicological Study on Female Wistar Rats

Measurements of the liver enzyme aspartate aminotransferase (ASAT) for a new compound and a control group of 34 female Wistar rats.

Keywords
datasets
Usage
asat
Details

The aim of this toxicological study is the proof of safety for the new compound. The data were originally given in Hothorn (1992) and later reproduced by Hauschke, Kieser and Hothorn (1999).

Format

A data frame with 34 observations on 2 variables.

asat

ASAT values.

group

a factor with levels "Compound" and "Control".

References

Pfl<U+00FC>ger, R. and Hothorn, T. (2002). Assessing equivalence tests with respect to their expected \(p\)-value. Biometrical Journal 44(8), 1015--1027. 10.1002/bimj.200290001

Aliases
  • asat
Examples
# NOT RUN {
## Proof-of-safety based on ratio of medians (Pflueger and Hothorn, 2002)
## One-sided exact Wilcoxon-Mann-Whitney test
wt <- wilcox_test(I(log(asat)) ~ group, data = asat,
                  distribution = "exact", alternative = "less",
                  conf.int = TRUE)

## One-sided confidence set
## Note: Safety cannot be concluded since the effect of the compound
##       exceeds 20 % of the control median
exp(confint(wt)$conf.int)
# }
Documentation reproduced from package coin, version 1.3-1, License: GPL-2

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