Expression matrix of deconvolved
cell-specific gene expression estimates for group 1.
se1
Standard error group 1
n1
Group 1 size
ghat2
Expression matrix of deconvolved
cell-specific gene expression estimates for group 2.
se2
Standard error group 2
n2
Group 2 size
standardize
Standardize contrast values
medianCenter
Median center rhat distributions for
each cell-type
nonNeg
Negative values not allowed such as in a
single channel microarray. Zero them if negative (a
conervative option)
Value
A matrix object with the result of contrasting the
average cell-specific expression profile of the two
groups, per cell-type (Size k by g where k is the number
of cells and g is the number of genes).
References
Shen-Orr SS, Tibshirani R, Khatri P, Bodian DL, Staedtler
F, Perry NM, Hastie T, Sarwal MM, Davis MM and Butte AJ
(2010). "Cell type-specific gene expression differences
in complex tissues." _Nature methods_, *7*(4), pp. 287-9.
ISSN 1548-7105, , .