Description
Find the false discovery rate for each gene in each
cell-type.
Usage
findSigGene(G, cc, y, rhat, csSAMData)
Arguments
G
Gene expression matrix of heterogenous tissue
measurements
cc
Matrix of cell-frequency measures per person
y
Numeric group association of each sample. Either
1 or 2.
rhat
Matrix of cell-specific contrasts for each
gene in each cell-type as computed for the original group
classification.
csSAMData
List object returned from fdrCsSAM.
Value
A matrix size k by g where k is the number of cell-types
and g is the number of genes. For each cell in the
matirx, listed is the FDR of the gene for a difference in
a given cell-type.
References
Shen-Orr SS, Tibshirani R, Khatri P, Bodian DL, Staedtler
F, Perry NM, Hastie T, Sarwal MM, Davis MM and Butte AJ
(2010). "Cell type-specific gene expression differences
in complex tissues." _Nature methods_, *7*(4), pp. 287-9.
ISSN 1548-7105, , .