drc (version 2.0-1)

vinclozolin: Vinclozolin from AR in vitro assay

Description

Dose-response experiment with vinclozolin in an AR reporter gene assay

Usage

data(vinclozolin)

source

Nellemann C., Dalgaard M., Lam H.R. and Vinggaard A.M. (2003) The combined effects of vinclozolin and procymidone do not deviate from expected additivity in vitro and in vivo, Toxicological Sciences, 71, 251--262.

Details

The basic dose-response experiment was repeated 6 times on different days. Chinese Hamster Ovary cells were exposed to various concentrations of vinclozolin for 22 hours and the resulting luminescense effects were recorded. Data are part of mixture experiment reported in Nellemann et al (2003).

Examples

vinclozolin.m1 <- drm(effect~conc, exper, data=vinclozolin, fct = LL.3())
plot(vinclozolin.m1, xlim=c(0,50), ylim=c(0,2800), conLevel=1e-4)

vinclozolin.m2 <- drm(effect~conc, data=vinclozolin, fct = LL.3())
plot(vinclozolin.m2, xlim=c(0,50), conLevel=1e-4, add=TRUE, type="none", col="red")

## Are the ED50 values indetical across experiments?
vinclozolin.m3 <- update(vinclozolin.m1, pmodels=data.frame(exper, exper, 1))
anova(vinclozolin.m3, vinclozolin.m1)  # No!