A Method to Search for Differentially Expressed Genes and to
Detect Recurrent Chromosomal Copy Number Aberrations
Description
A fold change rank based method is presented to search for genes with
changing expression and to detect recurrent chromosomal copy number
aberrations. This method may be useful for high-throughput biological
data (micro-array, sequencing, ...).
Probabilities are associated with genes or probes in the data set and
there is no problem of multiple tests when using this method. For
array-based comparative genomic hybridization data, segmentation
results are obtained by merging the significant probes detected.