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glycanr

Glycomics is rapidly emerging field in high-throughput biology that aims to systematically study glycan structures of a given protein, cell type or organic system. As within other high-throughput methods in biology (microarrays, metabolomics, proteomics), accuracy of high-throughput methods is highly affected by complicated experimental procedures leading to differences between replicates and the existence of batch effects, among others.

This package tries to fill the gap in N-glycan data analysis by providing easy to use functions for glycomics analysis. At the moment it is mostly oriented to data obtained by UPLC and LCMS analysis of Plasma and IgG glycome.

For a broader introduction take a look at "Introduction" vignette.

This project has received funding from:

  • the European Union’s Horizon FP7 research and innovation programme through the EU research project MIMOmics (Grant Agreement no. 305280),
  • the European Union’s Horizon 2020 research and innovation programme through the EU research project Back-UP (Grant Agreement no. 777090).

Install

From CRAN

install.packages('glycanr')

From GitHub

The package can be installed for example with devtools package.

install.packages('devtools')

Load the devtools package.

library(devtools)

Install the package.

install_github('iugrina/glycanr', build_vignette=TRUE)

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Install

install.packages('glycanr')

Monthly Downloads

51

Version

0.4.0

License

MIT + file LICENSE

Issues

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Stars

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Maintainer

Ivo Ugrina

Last Published

March 29th, 2021

Functions in glycanr (0.4.0)

iudt.translate

Translate names between computer readable and human readable for derived traits of IgG with UPLC
ildt.translate

Translate names between computer readable and human readable for derived traits of IgG with LCMS
mediannorm

Median Normalization of glycan data
glyco.plot

Plot data representing Glycans in boxplot or violin mode using ggplot2
ildt

Derived traits for Glycan peaks in IgG for LCMS
glyco.outliers

Discover outliers in glycan data
mpiu

Multiple plates IgG UPLC data example
iudt

Derived traits for Glycan peaks in IgG for UPLC
medianquotientnorm

Median Quotient Normalization of glycan data
refpeaknorm

Reference Peak Normalization of glycan data
mpiunorm

Normalized mpiu data
phdt

Derived traits for Glycan peaks in PLASMA for HPLC
tanorm

Total Area Normalization of glycan data
quantilenorm

Quantile Normalization of glycan data