Returns glycans normalized with Total Area Normalization approach.
Usage
tanorm(d, grouping = FALSE)
Arguments
d
data frame in long format containing glycan measurements
grouping
should data be normalized per groups
Value
Returns a data.frame with original glycan values substituted by normalized ones
Details
Input data frame should have at least the following three columns:
- gid - representing a unique name of a sample
- glycan - representing glycan names
- value - representing measured values
and if the grouping argument is TRUE it should also have column:
- groups - representing groupings (e.g. IgG1, IgG2 and IgG4)