ldPrimaryBoundary

Primary boundaries calculation of Lan-DeMets OBF and POC.

A gate-keeping procedure to test a primary and a secondary endpoint in a group sequential design with multiple interim looks. Computations related to group sequential primary and secondary boundaries. Refined secondary boundaries are calculated for a gate-keeping test on a primary and a secondary endpoint in a group sequential design with multiple interim looks. The choices include both the standard boundaries and the boundaries using error spending functions.
See Tamhane et al. (2018), "A gatekeeping procedure to test a primary and a secondary endpoint in a group sequential design with multiple interim looks", Biometrics, 74(1), 40-48.

Jiangtao Gou

gsrsb

Group Sequential Refined Secondary Boundary

Fengqing (Zoe) Zhang

ldPrimaryBoundary function

<dl><dt>tVec</dt>
<dd>a vector of information, gammaVec = sqrt(tVec).</dd>
<dt>alpha</dt>
<dd>significance level</dd>
<dt>type</dt>
<dd>type of sequential procedure. OBF is 1, POC is 2.</dd>
<dt>initIntvl</dt>
<dd>paramter for function uniroot (two numbers)</dd></dl>

Arguments

Author

Calculate Primary Boundaries, the Error Spending Approach — ldPrimaryBoundary

<dl>

<dt>tVec</dt>
<dd>a vector of information, gammaVec = sqrt(tVec).</dd>


<dt>alpha</dt>
<dd>significance level</dd>


<dt>type</dt>
<dd>type of sequential procedure. OBF is 1, POC is 2.</dd>


<dt>initIntvl</dt>
<dd>paramter for function uniroot (two numbers)</dd>

</dl>

ldPrimaryBoundary: Calculate Primary Boundaries, the Error Spending Approach

Description

Usage

Value

Arguments

Author

References

See Also