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gsrsb (version 1.2.1)

Group Sequential Refined Secondary Boundary

Description

A gate-keeping procedure to test a primary and a secondary endpoint in a group sequential design with multiple interim looks. Computations related to group sequential primary and secondary boundaries. Refined secondary boundaries are calculated for a gate-keeping test on a primary and a secondary endpoint in a group sequential design with multiple interim looks. The choices include both the standard boundaries and the boundaries using error spending functions. See Tamhane et al. (2018), "A gatekeeping procedure to test a primary and a secondary endpoint in a group sequential design with multiple interim looks", Biometrics, 74(1), 40-48.

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Version

Install

install.packages('gsrsb')

Monthly Downloads

148

Version

1.2.1

License

GPL-3

Maintainer

Jiangtao Gou

Last Published

July 4th, 2023

Functions in gsrsb (1.2.1)

initLocPeak

Find the Location of Maximum, Standard OBF and POC
ldInitLocPeak

Find the Location of Maximum, Error Spending Approach
cdBoundary

Lower and Upper Bounds Generator
genCorrMat

Correlation Matrix Generator
ldNominalSig

Calculate Nominal Significance, Error Spending Approach
secondaryBoundaryVecOrig

Calculate Refined Secondary Boundaries and Nominal Significance, Standard Approach
ldPrimaryBoundary

Calculate Primary Boundaries, the Error Spending Approach
primaryBoundaryVec

Calculate the Primary Boundaries
secondaryBoundaryVecLD

Calculate Refined Secondary Boundaries and Nominal Significance, the Error Spending Approach
psbTeXtable

Summarize Primary and Refined Secondary Boundaries in a TeX table
nominalSig

Calculate Nominal Significance, Standard Approach
secondaryBoundaryVec

Calculate Refined Secondary Boundaries and Nominal Significance
primaryBoundary

Calculate Primary Boundaries, Standard Approach
secondaryBoundary

Calculate the Refined Secondary Boundaries, Standard OBF and POC
refinedBoundary

Summarize Primary and Refined Secondary Boundaries, Nominal Significance
ldSecondaryBoundary

Calculate Refined Secondary Boundary, Error Spending Approach
ldSecControl

Difference between the Error Rate and Significance Level, the Error Spending Approach
secControl

Difference between the Error Rate and Significance Level, Standard Approach