ldSecControl

Calculate the difference between the error rate and significance level for the secondary endpoint, Lan-DeMets error spending approach.

A gate-keeping procedure to test a primary and a secondary endpoint in a group sequential design with multiple interim looks. Computations related to group sequential primary and secondary boundaries. Refined secondary boundaries are calculated for a gate-keeping test on a primary and a secondary endpoint in a group sequential design with multiple interim looks. The choices include both the standard boundaries and the boundaries using error spending functions.
See Tamhane et al. (2018), "A gatekeeping procedure to test a primary and a secondary endpoint in a group sequential design with multiple interim looks", Biometrics, 74(1), 40-48.

Jiangtao Gou

gsrsb

Group Sequential Refined Secondary Boundary

Fengqing (Zoe) Zhang

ldSecControl function

<dl><dt>ap</dt>
<dd>significance level for the primary endpoint</dd>
<dt>alpha</dt>
<dd>targeted significance level for the secondary endpoint</dd>
<dt>cvec</dt>
<dd>a vector of calculated primary boundaries</dd>
<dt>tVec</dt>
<dd>a vector of information, gammaVec = sqrt(tVec)</dd>
<dt>ExtrmLoc</dt>
<dd>an integer between 1 and K, locate the maximum of type I error of secondary endpoint</dd>
<dt>type</dt>
<dd>type of sequential procedures. Type 1 OBF d, Type 2 POC d.</dd></dl>

Arguments

Author

Difference between the Error Rate and Significance Level, the Error Spending Approach — ldSecControl

<dl>

<dt>ap</dt>
<dd>significance level for the primary endpoint</dd>


<dt>alpha</dt>
<dd>targeted significance level for the secondary endpoint</dd>


<dt>cvec</dt>
<dd>a vector of calculated primary boundaries</dd>


<dt>tVec</dt>
<dd>a vector of information, gammaVec = sqrt(tVec)</dd>


<dt>ExtrmLoc</dt>
<dd>an integer between 1 and K, locate the maximum of type I error of secondary endpoint</dd>


<dt>type</dt>
<dd>type of sequential procedures. Type 1 OBF d, Type 2 POC d.</dd>

</dl>

ldSecControl: Difference between the Error Rate and Significance Level, the Error Spending Approach

Description

Usage

Value

Arguments

Author

References

See Also