Calculate the difference between the error rate and significance level for the secondary endpoint, standard (original) approach.
secControl(d, alpha, cvec, gammaVec, ExtrmLoc, type = 2)difference between alpha and the calculated error rate.
boundary of secondary endpoint at the final look (a number, d_(K))
targeted significance level for the secondary endpoint
a vector of calculated primary boundaries
square root of information
an integer between 1 and K, locate the maximum of type I error of secondary endpoint
type of sequential procedures. Type 1 OBF d, Type 2 POC d.
Jiangtao Gou
Tamhane, A. C., Gou, J., Jennison, C., Mehta, C. R., and Curto, T. (2018). A gatekeeping procedure to test a primary and a secondary endpoint in a group sequential design with multiple interim looks. Biometrics, 74(1), 40-48.
ldSecControl