isr.fraction

Outputs the relevant fraction attributable to short half life for use in
<code>isr.deconv()</code> based on patient type (normal, obese, or non-insulin dependent
diabetes mellitus).

Calculates insulin secretion rates from C-peptide values
based on the methods described in Van Cauter et al. (1992)
<doi:10.2337/diab.41.3.368>. Includes functions to calculate estimated
insulin secretion rates using linear or cubic spline interpolation of
c-peptide values (see Eaton et al., 1980 <doi:10.1210/jcem-51-3-520>
and Polonsky et al., 1986 <doi:10.1172/JCI112308>) and to calculate
estimates of input coefficients (volume of distribution, short half life,
long half life, and fraction attributed to short half life) as described by
Van Cauter. Although the generated coefficients are specific to insulin
secretion, the two-compartment secretion model used here is useful for
certain applications beyond insulin.

Ken Stier

insulin.secretion

Insulin Secretion Rate Deconvolution

isr.fraction function

<dl><dt>subject.type</dt>
<dd>String for patient type.</dd></dl>

Arguments

C-Peptide Fraction Attributable to Short Half Life Lookup — isr.fraction

<dl>

<dt>subject.type</dt>
<dd>String for patient type.</dd>

</dl>

isr.fraction: C-Peptide Fraction Attributable to Short Half Life Lookup

Description

Usage

Value

Arguments

See Also

Examples