insulin.secretion (version 0.0.2)
Insulin Secretion Rate Deconvolution
Description
Calculates insulin secretion rates from C-peptide values
based on the methods described in Van Cauter et al. (1992)
. Includes functions to calculate estimated
insulin secretion rates using linear or cubic spline interpolation of
c-peptide values (see Eaton et al., 1980
and Polonsky et al., 1986 ) and to calculate
estimates of input coefficients (volume of distribution, short half life,
long half life, and fraction attributed to short half life) as described by
Van Cauter. Although the generated coefficients are specific to insulin
secretion, the two-compartment secretion model used here is useful for
certain applications beyond insulin.