mixtox (version 1.4.0)

cytotox: Cytotoxicity of Heavy Metal Ions and Ionic Liquids on MCF-7

Description

Chemicals include four heavy metal ions: \({\rm{NiN}}{{\rm{O}}_{\rm{3}}}\cdot 6{{\rm{H}}_{\rm{2}}}{\rm{O}}\)(Ni), \({\rm{ZnS}}{{\rm{O}}_{\rm{4}}} \cdot {\rm{7}}{{\rm{H}}_{\rm{2}}}{\rm{O}}\) (Zn), \({\rm{CuS}}{{\rm{O}}_{\rm{4}}} \cdot 5{{\rm{H}}_{\rm{2}}}{\rm{O}}\) (Cu), and \({\rm{MnC}}{{\rm{l}}_{\rm{2}}} \cdot 4{{\rm{H}}_{\rm{2}}}{\rm{O}}\) (Mn); four ionic liquids are 1-Octyl-3-methylimidazolium chloride (Omim), 1-Dodecyl-3-methylimidazolium chloride (Dmim), 1-Ethyl-3-methylimidazolium tetrafluoroborate (Emim), and 1-Hexyl-3-Methylimidazolium tetrafluoroborate (Hmim). The concentration-response data include the cytotoxicity of eight compounds, two mixtures designed by eecr, and ten mixtures designed by udcr. The fitting information of eight chemicals and a total of 12 mixtures.

Usage

data(cytotox)

Format

A list with concentration-response data of 8 chemicals, 2 eecr mixtures, 10 udcr mixtures, and associated fitting information.

Ni$x

a numeric vector of test concentrations

Ni$y

a numeric matrix of responses

Ni$name

test substances

Ni$concNum

the number of test concentrations

Ni$tierNum

the number of repetitions

Ni$type

type of test substance: single chemicals or mixtures

sgl$model

models used to fit the concentration-response data of individual chemicals

sgl$param

fitted coefficients of concentration-response curves

udcr.mix$model

models used to fit the concentration-response data of udcr mixtures

udcr.mix$param

fitted coefficients of the concentration-response curves corresponding to udcr.mix$model

$udcr.pct

the proportion of individual chemicals in udcr mixtures

Details

Quantal responses[0, 1] are needed for curve fitting using the following six equaitons: i.e., Weibull, Logit, Hill, BCL, GL, BCW. The following equation could transform continous responses to quantal ones: $$E = \frac{{{I_0} - {I_i}}}{{{I_0}}}$$ where \(I_0\) is the average of controls for inhibition tests or the average of the maximum effect for stimulation tests and \(I_i\) the average effect of the \(i^{th}\) treatment.

Examples

# NOT RUN {
# example 1
## Retrive the toxicity data of Ni on MCF-7.
cytotox$Ni

# example 2
## Retrive the toxicity information of ten udcr mixtures on MCF-7.
cytotox$udcr.mix
# }