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mixtox (version 1.4.0)

Dose Response Curve Fitting and Mixture Toxicity Assessment

Description

Curve Fitting of monotonic(sigmoidal) & non-monotonic(J-shaped) dose-response data. Predicting mixture toxicity based on reference models such as 'concentration addition', 'independent action', and 'generalized concentration addition'.

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Install

install.packages('mixtox')

Monthly Downloads

177

Version

1.4.0

License

GPL-2

Issues

Pull Requests

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Repository

https://github.com/ichxw/mixtox

Maintainer

Xiangwei Zhu

Last Published

June 20th, 2022

Functions in mixtox (1.4.0)

Toxicity of Seven Antibiotics on Photobacteria

Mixture Toxicity Prediction Based on Concentration Addition

NOEC and LOEC Calculation

critical value for Dunnett's test

Effect Concentration Calculation for Sigmoidal Models

Mixture Effect Predicted by CA at Particular Concentration of a Mixture

Cytotoxicity of Heavy Metal Ions and Ionic Liquids on MCF-7

Effect Calculation for All Ninteen Curves

Mixture Effect Predicted by IA at Particular Concentration of a Mixture

Calculating benchmark dose (BMD) and lower limit of benchmark dose (BMDL)

Mixture Toxicity Prediction Using GCA (Hill_two)

Calculating Confidence Intervals

Non-monotonic Concentration-response Data

Ploting concentration response curve

Effect Concentration Calculation for J-shaped Models

Uniform Design Table

Dose-Response Curve Fitting and Mixture Toxicity Assessment

Jacobian Matrix Calculation

Residual Normal QQ Plot

Mixture Toxicity Prediction Based on Independent Action

Read curve fitting information

List Requested Equations

Mixture Toxicity Prediction Using GCA (General)

Read dose-response data

Find Optimal Starting values for Curve Fitting

Starting Values for 13 Sigmoidal and 4 Hormetic Models