Simulated Data Set for comparing objective functions
Oral_1CPT -- 1 Compartment Model with Oral Absorption Simulated Data from ACOP 2016
Return VarCorr for nlmixr nlme
Add multiple covariates to a given model, sequentially or all at once
2 Compartment Model with Michaelis-Menten Clearance
2 Compartment Model
1 Compartment Model w/ Michaelis-Menten Elimination
Bolus_1CPT -- 1 Compartment Model Simulated Data from ACOP 2016
Infusion_1CPT -- 1 Compartment Model Simulated Data from ACOP 2016
Output nlmixr format for dynmodel
Add covariate expression to a function string
Adding covariate to a given variable in an nlmixr model expression
Return composite nlme/focei to nlme
Backward covariate search
Log-likelihood using Gaussian Quadrature
Return composite saem/focei to saem
Cox Box, Yeo Johnson and inverse transformation
FOCEi fit
Bootstrap nlmixr fit
Control Options for FOCEi
Configure an SAEM model
Convert fit to classic dynmodel object
Add table information to nlmixr fit object without tables
Get the FOCEi theta specification for the model
NPDE calculation for nlmixr
Get the FOCEi theta or eta specification for model.
nlmixr ini block handling
Calculate gnlmm variance-covariance matrix of fixed effects
Add CWRES
Generalized Cholesky Matrix Decomposition
Convert fit to FOCEi style fit
Bootstrap data
Inverse Guassian absorption model
instant.stan.extension.
Forward covariate search
Fit/Evaulate FOCEi
Generate an SAEM model
Produce trace-plot for fit if applicable
Calculate gnlmm variance-covariance matrix of random effects
Return dynmodel variable translation function
Return dynmodel variable translation function
Control Options for dynmodel
Fit a non-population dynamic model using mcmc
nlmixr model block
This gets the parsed data in the lower-level manner that nlmixr expects.
Stepwise Covariate Model-selection (SCM) method
Fit a non-population dynamic model
Forward covariate selection for nlme-base non-linear mixed effect models
Creating Hockey-stick covariates
Covariance matrix by Fisher Information Matrix via linearization
Sets nodes and weights of Gauss-Hermite quadrature
Parent/Metabolite dataset
Plot of a non-population dynamic model fit
Fit a generalized nonlinear mixed-effect model
Initializing covariates before estimation
Convert/Format the data appropriately for nlmixr
Functions to assist with setting initial conditions and boundaries
Simulate a nlmixr solved system
Access the model list information for nlmixr's nlme user functions
Get the optimal forward difference interval by Gill83 method
Get initial estimate for bres SAEM.
nlmixrUI.saem.distribution
Get SAEM distribution
Fit nlme-based mixed-effect model using ODE implementation
Create a gradient function based on gill numerical differences
Print x using the message facility
GOF plots for nlme-based mixed-effect models
Fit nlme-based linear compartment mixed-effect model using closed form solution
Get parameters that are fixed for SAEM
concentrations from a linear compartment model
Get error names for SAEM
Get saem initilization list
Return RxODE model with predictions appended
Perform normalization of the covariate
Print summary of a non-population dynamic model fit using mcmc
Print a gnlmm fit
Return the objective function
Create categorical covariates
Augmented Prediction for nlmixr fit
Summary of a non-population dynamic model fit
Print an SAEM model fit summary
Calculate Hessian
nlmixr fits population PK and PKPD non-linear mixed effects models.
Extract the nlmixr bound information from a function.
Predict a nlmixr solved system
Get parameters that are fixed
Messages the nlmixr logo...
Get a posthoc estimate of x
Get the FOCEi initializations
Plot a nlmixr data object
Fit a nlmixr model
Get ETA names
Find the assignments in R expression
Plot an SAEM model fit
Create a run summary word document
Generate SAEM initial estimates for THETA.
SAEM's init$omega
Single Dose Phenobarbitol PK/PD
Print an SAEM model fit summary
Print UI function
Plot of a non-population dynamic model fit using mcmc
Converting nlmixr objects to dynmodel objects
nlmixrBounds.focei.upper.lower
Get upper/lower/names for THETAs
Convert data to RxODE format (depreciated)
Create the nlme specs list for nlmixr nlme solving
Extract residuals from the FOCEI fit
Fit an SAEM model
Return RxODE model with predictions appended
nlmixrUI.saem.model.omega
Get the SAEM model Omega
Get the Parameter function with THETA/ETAs defined
Get THETA names for nlmixr's SAEM
Get the SAEM model$res.mod code
Create the nlme parameter transform function from the UI object.
Vpc function for nlmixr
Visual predictive check (VPC) for nlmixr nlme objects
nlmixTest function for testing
Generic for nlmixr estimation methods
Get the variance for the nlme fit process based on UI
Get initial estimate for bres SAEM.
Generate saem.fit user function.
Prepares the UI function and returns a list.
Get model$log.eta for SAEM
Validate nlmixr
Get initial estimate for ares SAEM.
Get the eta->eta.trans for SAEM
Display nlmixr's version
Generate SAEM model list
Output table/data.frame options
Create a large output based on a nlmixr fit
Linearly re-parameterize the model to be less sensitive to rounding errors
Removing multiple covariates
Return the square root of general square matrix A
Objects exported from other packages
Calculate the inverse preconditioning matrix
Set/get Objective function type for a nlmixr object
Multiple dose theophylline PK data
Prediction after a gnlmm fit
Print a non-population dynamic model fit object
Control Options for SAEM
Multiple dose theophylline PK data
Remove covariate from function string
Nelder-Mead simplex search
Pump failure example dataset
Produce trace-plot for fit if applicable
Remove covariate expression from a function string
Pregnant Rat Diet Experiment
VPC for nlmixr saemFit objects
VPC based on ui model
Set the covariance type based on prior calculated covariances
Warfarin PK/PD data