rxUpdateEtas

This is the d(eta)/d(theta) list where there is a
d(eta)/d(theta) matrix for each subject

DnDhS

This is the change in theta observed between steps.

This is the ETA initial condition matrix

initS

Acceptance criteria for the new eta. |eta| &lt; acceptNS for the new eta
to be accepted.

acceptNS

This updates the ETA initial estimates based on the knowledge of d(eta)/d(theta)

internal

Fit and compare nonlinear mixed-effects models in differential
equations with flexible dosing information commonly seen in pharmacokinetics
and pharmacodynamics (Almquist, Leander, and Jirstrand 2015
<doi:10.1007/s10928-015-9409-1>). Differential equation solving is
by compiled C code provided in the 'RxODE' package
(Wang, Hallow, and James 2015 <doi:10.1002/psp4.12052>).

Wenping Wang

nlmixr

Nonlinear Mixed Effects Models in Population Pharmacokinetics
and Pharmacodynamics

rxUpdateEtas: Update ETAs based on d(eta)/d(theta)

Description

Usage

Arguments