Get the FOCEi theta specification for the model
Calculate gnlmm variance-covariance matrix of random effects
Convert focei fit to a data.frame
Get the FOCEi theta or eta specification for model.
Get the eta->eta.trans for SAEM
Parameters for a linear compartment model for SAEM
Print an SAEM model fit summary
Get initial estimate for bres SAEM.
Build linear solved information based on defined parameters.
Get THETA names for nlmixr's SAEM
Get the Parameter function with THETA/ETAs defined
FOCEI Fit for nlmixr
concentrations from a linear compartment model
Plot of a non-population dynamic model fit using mcmc
Calculate the Gradient for an individual
nlmixr fits population PK and PKPD non-linear mixed effects models.
Get error names for SAEM
Augmented Prediction for nlmixr fit
Fit a non-population dynamic model using mcmc
Returns the gradient for FOCEi environment
Fit a generalized nonlinear mixed-effect model
Forward covariate selection for nlme-base non-linear mixed effect models
Plot a focei.fit plot
Extract the Nlmixr bound information from a function.
Fit nlme-based linear compartment mixed-effect model using closed form solution
Get initial estimate for ares SAEM.
Fit nlme-based mixed-effect model using ODE implementation
Get saem initilization list
Sets nodes and weigts of Gauss-Hermite quadrature
Create the nlme parameter transform function from the UI object.
Generate an SAEM model
Return composite nlme/focei to nlme
Parent/Metabolite dataset
Update ETAs based on d(eta)/d(theta)
FOCEI ETA setup,
Prediction after a gnlmm fit
Extract the fitted values from the model
Extract log likelihood for focei fit
Access the model list information for nlmixr's nlme user functions
Visual predictive check (VPC) for nlmixr nlme objects
Validate nlmixr
Get a list of directories for inclusion
Predict a nlmixr solved system
Create the nlme specs list for nlmixr nlme solving
Messages the nlmixr logo...
Get ETA names
Plot of a non-population dynamic model fit
Generate saem.fit user function.
Get the FOCEi initilizations
Clear memoise cache for nlmixr
instant.stan.extension.
Get the Hessian for the environment
Convert/Format the data appropriately for nlmixr
GOF plots for nlme-based mixed-effect models
Multiple dose Theophiline PK data
nlmixrBounds.focei.upper.lower
Get upper/lower/names for THETAs
Generate SAEM model list
Get the variance for the nlme fit process based on UI
Get model$log.eta for SAEM
Return RxODE model with predictions appended
Extract the number of observations for the focei fit
Convert NONMEM/Monolix data to RxODE/nlmixr style data
Inverse Guassian absorption model
Nelder-Mead of simplex search
VPC for nlmixr saemFit objects
Generate SAEM initial estimates for THETA.
VPC based on ui model
Print a focei fit
Print x using the message facility
Objects exported from other packages
Print a gnlmm fit
nlmixrUI.saem.model.omega
Get the SAEM model Omega
Pump failure example dataset
Simulate a nlmixr solved system
Get -Grad for individual
Get the SAEM model$res.mod code
SAEM's init$omega
Prepares the UI function and returns a list.
Parameter history extraction
Summary of a non-population dynamic model fit using mcmc
Control Options for SAEM
Cleanup saem_fit environment by removing dll after the object is no logner used by R.
Pregnant Rat Diet Experiment
Print UI function
Plot an SAEM model fit
Fit a nlmixr model
Find the assignments in R expression
Dispaly nlmixr's version
Vpc function for nlmixr
Extract variance/covariance matrix for FOCEI fit
Print a non-population dynamic model fit object
Print an SAEM model fit summary
Summary of a non-population dynamic model fit using mcmc
Extract residuals from the FOCEI fit
Fit an SAEM model
Solve the FOCEI inner problem
Get -LLIK for individual
FOCEI THETA setup,
Summary of a non-population dynamic model fit
Multiple dose Theophiline PK data
Produce trace-plot for fit if applicable
Get the likelihood slope for ETA
Get the Function pointers for the LBJ'S routine
Bolus_1CPT -- 1 Compartment Model Simulated Data from ACOP 2016
2 Compartment Model
1 Compartment Model w/ Michelis Menton Elimination
2 Compartment Model with Michelis Menton Clearance
Convert fit to FOCEi style fit
Get the likelihood for ETA
Simulated Data Set for comparing objective functions
RxODE_focei_finalize_llik
Finalize likelihood environment
Oral_1CPT -- 1 Compartment Model with Oral Absorption Simulated Data from ACOP 2016
Infusion_1CPT -- 1 Compartment Model Simulated Data from ACOP 2016
Return composite saem/focei to saem
Bootstrap data
Calculate gnlmm variance-covariance matrix of fixed effects
Configure an SAEM model
Fit a non-population dynamic model
Construct RxODE linCmt function