theo_sd

This datastart is the day 1 concentrations of the
Theophiline data that is included in the nlme/NONMEM.

datasets

Fit and compare nonlinear mixed-effects models in differential
equations with flexible dosing information commonly seen in pharmacokinetics
and pharmacodynamics (Almquist, Leander, and Jirstrand 2015
<doi:10.1007/s10928-015-9409-1>). Differential equation solving is
by compiled C code provided in the 'RxODE' package
(Wang, Hallow, and James 2015 <doi:10.1002/psp4.12052>).

Wenping Wang

nlmixr

Nonlinear Mixed Effects Models in Population Pharmacokinetics
and Pharmacodynamics

Matthew Fidler

Yuan Xiong

Rik Schoemaker

Justin Wilkins

Richard Hooijmaijers

Teun Post

Robert Leary

Mirjam Trame

Hadley Wickham

Dirk Eddelbuettel

Johannes Pfeifer

Robert B. Schnabel

Elizabeth Eskow

Emmanuelle Comets

Audrey Lavenu

Marc Lavielle

David Ardia

Bill Denney

Daniel C. Dillon

Katharine Mullen

Ben Goodrich

theo_sd function

A data frame with 144 rows by 7 columns<dl class="dl-horizontal">
 <dt>ID</dt><dd>Subject ID</dd>
 <dt>TIME</dt><dd>Time (hrs)</dd>
 <dt>DV</dt><dd>Dependant Variable, Theophiline Concentration</dd>
 <dt>AMT</dt><dd>Dose Amount/kg</dd>
 <dt>EVID</dt><dd>RxODE/nlmixr event ID (not NONMEM's)</dd>
 <dt>CMT</dt><dd>Compartment Number</dd>
 <dt>WT</dt><dd>Weight (kg)</dd>
</dl>

Format

Multiple dose Theophilline PK data — theo_sd

A data frame with 144 rows by 7 columns<dl class='dl-horizontal'>
 <dt>ID</dt><dd>Subject ID</dd>
 <dt>TIME</dt><dd>Time (hrs)</dd>
 <dt>DV</dt><dd>Dependant Variable, Theophiline Concentration</dd>
 <dt>AMT</dt><dd>Dose Amount/kg</dd>
 <dt>EVID</dt><dd>RxODE/nlmixr event ID (not NONMEM's)</dd>
 <dt>CMT</dt><dd>Compartment Number</dd>
 <dt>WT</dt><dd>Weight (kg)</dd>
</dl>

Multiple dose Theophilline PK data

theo_sd: Multiple dose Theophilline PK data

Description

Usage

Arguments

Format