add_variability

Defines a model string for a parameter, optionally adding inter-individual
variability.

Automated population pharmacokinetic modeling framework for
data-driven initialisation, model evaluation, and metaheuristic
optimization. Supports genetic algorithms, ant colony optimization,
tabu search, and stepwise procedures for automated model selection
and parameter estimation within the nlmixr2 ecosystem.

Zhonghui Huang

nlmixr2auto

Automated Population Pharmacokinetic Modeling

Joseph Standing

Matthew Fidler

Frank Kloprogge

add_variability function

<dl><dt>param_name</dt>
<dd>Character. The name of the parameter.</dd>
<dt>eta_flag</dt>
<dd>Integer. If 1, inter-individual variability is added;
otherwise, it is not.</dd>
<dt>param_table</dt>
<dd>Data frame. A table containing parameter details with
columns <code>Name</code>, <code>init</code>, and optionally bounds like <code>lb</code> and <code>ub</code>.</dd>
<dt>param.type</dt>
<dd>Integer. Transformation type: 1=Exponential, 2=Logistic.
Defaults to 1.</dd></dl>

Arguments

Author

Add inter-individual variability to a parameter — add_variability

<dl>

<dt>param_name</dt>
<dd>Character. The name of the parameter.</dd>


<dt>eta_flag</dt>
<dd>Integer. If 1, inter-individual variability is added;
otherwise, it is not.</dd>


<dt>param_table</dt>
<dd>Data frame. A table containing parameter details with
columns <code>Name</code>, <code>init</code>, and optionally bounds like <code>lb</code> and <code>ub</code>.</dd>


<dt>param.type</dt>
<dd>Integer. Transformation type: 1=Exponential, 2=Logistic.
Defaults to 1.</dd>

</dl>

add_variability: Add inter-individual variability to a parameter

Description

Usage

Value

Arguments

Author

Examples