nlmixr2auto (version 1.0.0)

build_odeline: Build ODE model lines for pharmacokinetic modeling

Description

Constructs a system of ordinary differential equations (ODEs) for pharmacokinetic modeling with various configurations including different absorption models, compartmental structures, and elimination kinetics.

Usage

build_odeline(
  mm = 0,
  no.cmpt = 1,
  route = "bolus",
  abs.bio = 0,
  abs.type = 1,
  abs.delay = 0
)

Value

A character vector containing ODE equations for the specified configuration. Includes differential equations for drug compartments, absorption models, and derived parameters.

Arguments

mm

Michaelis-Menten elimination flag. 0 = linear elimination (default), 1 = Michaelis-Menten elimination.

no.cmpt

Number of compartments. Supported values: 1 (central only), 2 (central + peripheral), or 3 (central + 2 peripheral).

route

Administration route. Options: "bolus" (IV), "oral", or "mixed_iv_oral".

abs.bio

Bioavailability estimation flag. 0 = no bioavailability estimation (default), 1 = include bioavailability parameter (F1).

abs.type

Absorption type for oral route:

• 1 = First-order absorption (default)

• 2 = Zero-order absorption

• 3 = Sequential zero-first order absorption

• 4 = Dual zero-first order absorption

abs.delay

Absorption delay type:

• 0 = No delay (default)

• 1 = Lag time (tlag)

• 2 = Transit compartment model

Author

Zhonghui Huang

Details

Parameter Constraints: The function includes error checking for incompatible parameter combinations:

• abs.bio=1 cannot be used with abs.type=4 or abs.delay=3

• Dual absorption (abs.type=4) not supported for mixed routes

Examples

# Two-compartment model with first-order absorption
build_odeline(no.cmpt = 2, route = "oral")

# One-compartment IV model with Michaelis-Menten elimination
build_odeline(mm = 1, route = "bolus")