The example PK model that were used in sensitivity testing.
Three examples are included: Flip-flop pharmacokinetic model,
one-compartment toxicokinetic model from httk (Pearce et al. 2017),
and acetaminophen pharmacokinetic model (Zurlinden et al. 2016).
Usage
FFPK(params, time, dose = 1)
pbtk1cpt_model()
pbpk_apap_model()
Arguments
params
a numeric vector to define the input parameter value.
time
a numeric vector to define the given time point(s).
dose
a numeric value to define the given dose in flip-flop model.
Functions
pbtk1cpt_model: Download pbtk1cpt.model file.
pbpk_apap_model: Download pbpk_apap.model file.
References
Pearce, R. G., Setzer, R. W., Strope, C. L., Wambaugh, J. F., & Sipes, N. S. (2017).
httk: R package for high-throughput toxicokinetics.
Journal of Statistical Software, 79(4), 1-26.
Zurlinden, T. J., & Reisfeld, B. (2016).
Physiologically based modeling of the pharmacokinetics of acetaminophen and
its major metabolites in humans using a Bayesian population approach.
European journal of drug metabolism and pharmacokinetics, 41(3), 267-280.
# NOT RUN {params <- c(F = 0.9, KA = 1.2, KE = 0.2, V = 1.5)
t <- seq(0, 12, 0.1)
C <-FFPK(params = params, time = t)
plot(t, C, type = "l", xlab = "time", ylab = "concentration")
# }