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precautionary (version 0.1-2)

Safety Diagnostics for Dose-Escalation Trial Designs

Description

Enhances various R packages that support the design and simulation of phase 1 dose-escalation trials, adding diagnostics to examine the safety characteristics of these designs in light of expected inter-individual variation in pharmacokinetics and pharmacodynamics. See Norris (2020), "Retrospective analysis of a fatal dose-finding trial" .

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Version

Install

install.packages('precautionary')

Monthly Downloads

36

Version

0.1-2

License

MIT + file LICENSE

Maintainer

David C. Norris

Last Published

August 1st, 2020

Functions in precautionary (0.1-2)

test_draw_samples

Test performance of draw_samples function
simulate_trials

Simulate trials defined via package escalation
safety_kable

Output a kable for a simulation summary of class safetytab
summary.precautionary

Specialize a method defined in package 'escalation' for class 'simulations'
simulation_function.u_i

Get a function that simulates dose-escalation trials using latent u_i
precautionary-package

Safety Diagnostics for Dose-Escalation Trial Designs
print.hyper

Specialize print method defined for class escalation::simulations
print.precautionary

Specialize print method for objects of class escalation::simulations
phase1_sim

Override escalation::phase1_sim to incorporate latent toxicity tolerances
plot,mtdi_generator-method

Visualize n samples from an mtdi_generator object
plot,mtdi_distribution-method

Visualize an mtdi_distribution object
extend

Extend an existing simulation, using one of several stopping criteria
format.safetytab

Format a phase 1 trial safety tabulation to show significant digits only
as.data.table.precautionary

Convert an object of class c('precautionary','simulations') to a data.table
hyper_mtdi_lognormal-class

Hyperprior for lognormal MTDi distributions
mtdi_lognormal-class

A lognormal MTDi distribution
cohorts_of_n

Override escalation::cohorts_of_n to include latent toxicity tolerances