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precautionary (version 0.1-2)
Safety Diagnostics for Dose-Escalation Trial Designs
Description
Enhances various R packages that support the design and simulation
of phase 1 dose-escalation trials, adding diagnostics to examine
the safety characteristics of these designs in light of expected
inter-individual variation in pharmacokinetics and pharmacodynamics.
See Norris (2020), "Retrospective analysis of a fatal dose-finding
trial" .