precautionary v0.1-2

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Safety Diagnostics for Dose-Escalation Trial Designs

Enhances various R packages that support the design and simulation of phase 1 dose-escalation trials, adding diagnostics to examine the safety characteristics of these designs in light of expected inter-individual variation in pharmacokinetics and pharmacodynamics. See Norris (2020), "Retrospective analysis of a fatal dose-finding trial" <arXiv:2004.12755>.

Functions in precautionary

Name Description
test_draw_samples Test performance of draw_samples function
simulate_trials Simulate trials defined via package escalation
safety_kable Output a kable for a simulation summary of class safetytab
summary.precautionary Specialize a method defined in package 'escalation' for class 'simulations'
simulation_function.u_i Get a function that simulates dose-escalation trials using latent u_i
precautionary-package Safety Diagnostics for Dose-Escalation Trial Designs
print.hyper Specialize print method defined for class escalation::simulations
print.precautionary Specialize print method for objects of class escalation::simulations
phase1_sim Override escalation::phase1_sim to incorporate latent toxicity tolerances
plot,mtdi_generator-method Visualize n samples from an mtdi_generator object
plot,mtdi_distribution-method Visualize an mtdi_distribution object
extend Extend an existing simulation, using one of several stopping criteria
format.safetytab Format a phase 1 trial safety tabulation to show significant digits only
as.data.table.precautionary Convert an object of class c('precautionary','simulations') to a data.table
hyper_mtdi_lognormal-class Hyperprior for lognormal MTDi distributions
mtdi_lognormal-class A lognormal MTDi distribution
cohorts_of_n Override escalation::cohorts_of_n to include latent toxicity tolerances
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Vignettes of precautionary

Name
Intro.Rmd
precautionary-package.bib
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Details

Type Package
Date 2020-08-01
URL https://precisionmethods.guru/
License MIT + file LICENSE
VignetteBuilder knitr, rmarkdown
Encoding UTF-8
NeedsCompilation no
RoxygenNote 7.1.1
Collate 'enhance.R' 'precautionary-package.R' 'toxicity_generators.R' 'simulate_trials.R'
Packaged 2020-08-01 13:14:40 UTC; david
Repository CRAN
Date/Publication 2020-08-01 13:40:02 UTC

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