A trial simulation carried through a predetermined number of replications
may not achieve desired precision as judged by Monte Carlo standard errors
(MCSE) of estimated toxicity counts. This method enables simulations of
class c('precautionary','simulations') to be extended until a given
level of precision has been achieved on expected counts of enrollment and
DLTs, or (optionally) for a fixed additional number of simulations.
extend(sims, num_sims = NULL, target_mcse = 0.05)An existing object of class c('precautionary','simulations')
Optionally, a fixed number of additional replications to accumulate
Optionally, an MCSE constraint to be imposed on expected counts of DLTs, non-DLTs, and Total enrollment.
An extended simulation of same class as sims.
See examples under simulate_trials and format.safetytab.