check.input: Check qpNCA function arguments for validity

Description

Checks whether all function arguments are valid and entered column names are present in input data See qpNCA for description of the arguments

Usage

check.input(
  x,
  by = NA,
  nomtimevar = NA,
  timevar = NA,
  depvar = NA,
  bloqvar = NA,
  loqvar = NA,
  loqrule = NA,
  includeCmax = NA,
  exclvar = NA,
  plotdir = NA,
  timelab = NA,
  deplab = NA,
  tau = NA,
  tstart = NA,
  tend = NA,
  teval = NA,
  covariates = NA,
  dose = NA,
  factor = NA,
  reg = NA,
  ss = NA,
  route = NA,
  method = NA
)

Arguments

data.frame

column names in x indicating grouping variables

nomtimevar

variable name containing the nominal sampling time after dose

timevar

variable name containing the actual sampling time after dose

depvar

variable name containing the dependent variable (e.g., concentration)

bloqvar

variable name containing the BLOQ flag (0: no, 1: yes)

loqvar

variable name containing the LOQ value

loqrule

rule number to be applied to the LOQ values in the curve; x$loqrule overrides if provided

includeCmax

include Cmax in half-life estimation? (y/n); x$includeCmax overrides if provided

exclvar

variable name indicating points to be excluded in half-life estimation (these should have exclvar = 1)

plotdir

directory where regression plots (.PNG) will be saved; NA gives default location, NULL skips regression plots

timelab

label for time axis in regression plots

deplab

label for dependent variable axis in regression plots

tau

dosing interval (for multiple dosing); NA (default) if single dose; x$tau overrides

tstart

start time of partial AUC (start>0); NA (default) if not requested; x$tstart overrides

tend

end time of partial AUC; NA (default) if not requested; x$tend overrides

teval

user selected AUC interval (starting at t=0); NA (default) if not requested; x$teval overrides

covariates

covariates dataset; Must contain the dose variable

dose

variable containing the dose amount

factor

conversion factor for CL and V calculation (e.g. dose in mg, conc in ng/mL, factor=1000); x$factor overrides if provided

reg

regimen, "SD" or "MD"; x$reg overrides if provided

is steady state reached (y/n); x$ss overrides if provided

route

route of drug administration ("EV","IVB", "IVI"); x$route overrides if provided

method

method for trapezoidal rule; x$method overrides if provided

Value

Check results