trap

method:<ul>
<li>1: linear up - linear down</li>
<li>2: linear up - logarithmic down</li>
<li>3: linear before Tmax, logarithmic after Tmax</li>
</ul>

method

Calculates AUC using the trapezoidal method. Assumes data represent a single profile.
Despite choice of method, only linear interpolation is used
for areas of intervals beginning or ending with y: 0.

Computes noncompartmental pharmacokinetic parameters
for drug concentration profiles.  For each profile, data
imputations and adjustments are made as necessary and
basic parameters are estimated. Supports single dose, multi-dose,
and multi-subject data.  Supports steady-state calculations
and various routes of drug administration. See ?qpNCA and vignettes.
Methodology follows Rowland and Tozer (2011, ISBN:978-0-683-07404-8),
Gabrielsson and Weiner (1997, ISBN:978-91-9765-100-4), and
Gibaldi and Perrier (1982, ISBN:978-0824710422).

Jan Huisman

qpNCA

trap: Calculate Area Under the Curve Using Trapezoids

Description

Usage

Arguments

Value