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skewr (version 1.4.2)

Visualize Intensities Produced by Illumina's Human Methylation 450k BeadChip

Description

The skewr package is a tool for visualizing the output of the Illumina Human Methylation 450k BeadChip to aid in quality control. It creates a panel of nine plots. Six of the plots represent the density of either the methylated intensity or the unmethylated intensity given by one of three subsets of the 485,577 total probes. These subsets include Type I-red, Type I-green, and Type II.The remaining three distributions give the density of the Beta-values for these same three subsets. Each of the nine plots optionally displays the distributions of the "rs" SNP probes and the probes associated with imprinted genes as series of 'tick' marks located above the x-axis.

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Version

Version

1.4.2

License

GPL-2

Maintainer

Ryan Putney

Last Published

February 15th, 2017

Functions in skewr (1.4.2)

panelPlots

Plot the distributions of the probe intensities and the components of the skew-normal mixture model
getBarcodes

Get barcodes from idat file names
getSNparams

Estimate parameters for finite mixture of Skew-Normal distributions
getMethyLumiSet

Read idat files and create a MethyLumiSet object
preprocess

Normalize a MethyLumiSet object using some popular choices
subsetProbes

Conveniently subset probes by type and retrieve the methylated or unmethylated intensities