ZIP: Delta synergy score based on zero interaction potency (ZIP) model
Description
A function to calculate delta synergy score based on zero interaction potency (ZIP) model
Usage
ZIP(response.mat, correction = TRUE)
Arguments
response.mat
a dose-response matrix with concentrations as row names and column names
correction
a parameter to specify if baseline correction is used or not. Defaults to TRUE.
Value
A matrix of delta scores for all the dose pairs for a drug combination. For a does pair with at least one zero concentration, 0 is used as the synergy score.
References
Yadav B, Wennerberg K, Aittokallio T, Tang J. Searching for Drug Synergy in Complex Dose-Response Landscape Using an Interaction Potency Model.
Computational and Structural Biotechnology Journal 2015; 13: 504-513.