tcplfit2: A Concentration-Response Modeling Utility

Welcome to the GitHub repository for the tcplfit2 package.

The tcplfit2 R package performs basic concentration-response curve fitting. The original tcplFit() function in the ToxCast Data Analysis Pipeline (tcpl) R package performed basic concentration-response curvefitting to 3 models. With tcplfit2, the core tcpl concentration-response functionality has been expanded to process diverse high-throughput screen (HTS) data generated at the US Environmental Protection Agency, including targeted ToxCast, high-throughput transcriptomics (HTTr) and high-throughput phenotypic profiling (HTPP). tcplfit2 can be used independently to support analysis for diverse chemical screening efforts.

If you are interested in contributing or want to report a bug, please submit a issue or start a discussion.

To install the current development version, run the following command:

devtools::install_github("USEPA/CompTox-ToxCast-tcplfit2")

Disclaimer

The United States Environmental Protection Agency (EPA) GitHub project code is provided on an “as is” basis and the user assumes responsibility for its use. EPA has relinquished control of the information and no longer has responsibility to protect the integrity, confidentiality, or availability of the information. Any reference to specific commercial products, processes, or services by service mark, trademark, manufacturer, or otherwise, does not constitute or imply their endorsement, recommendation or favoring by EPA. The EPA seal and logo shall not be used in any manner to imply endorsement of any commercial product or activity by EPA or the United States Government.