acgnlsobj

GNLS objective function set to y for gnls solver.

The tcplfit2 R package performs basic concentration-response curve fitting. The original tcplFit() function in the tcpl R package performed basic concentration-response curvefitting to 3 models. With tcplfit2, the core tcpl concentration-response functionality has been expanded to process diverse high-throughput screen (HTS) data generated at the US Environmental Protection Agency, including targeted ToxCast, high-throughput transcriptomics (HTTr) and high-throughput phenotypic profiling (HTPP). tcplfit2 can be used independently to support analysis for diverse chemical screening efforts.

Madison Feshuk

tcplfit2

A Concentration-Response Modeling Utility

Thomas Sheffield

Jason Brown

Sarah E. Davidson-Fritz

Lindsay Knupp

Zhihui Zhao

Richard S Judson

Katie Paul Friedman

acgnlsobj function

<dl><dt>x</dt>
<dd>Concentration.</dd>
<dt>y</dt>
<dd>Desired activity level.</dd>
<dt>tp</dt>
<dd>Gain-loss Model Top Parameter.</dd>
<dt>ga</dt>
<dd>Gain AC50.</dd>
<dt>p</dt>
<dd>Gain power.</dd>
<dt>la</dt>
<dd>Loss AC50.</dd>
<dt>q</dt>
<dd>Loss power.</dd></dl>

Arguments

AC GNLS Objective Function — acgnlsobj

<dl>

<dt>x</dt>
<dd>Concentration.</dd>


<dt>y</dt>
<dd>Desired activity level.</dd>


<dt>tp</dt>
<dd>Gain-loss Model Top Parameter.</dd>


<dt>ga</dt>
<dd>Gain AC50.</dd>


<dt>p</dt>
<dd>Gain power.</dd>


<dt>la</dt>
<dd>Loss AC50.</dd>


<dt>q</dt>
<dd>Loss power.</dd>

</dl>

acgnlsobj: AC GNLS Objective Function

Description

Usage

Value

Arguments