trioGxE v0.1-1

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A data smoothing approach to explore and test gene-environment interaction in case-parent trio data

The package contains functions that 1) estimates gene-environment interaction between a SNP and a continuous non-genetic attribute by fitting a generalized additive model to case-parent trio data, 2) produces graphical displays of estimated interaction, 3) performs permutation test of gene-environment interaction; 4) simulates informative case-parent trios.

Functions in trioGxE

Name Description
hypoTrioDat Simulated data for a hypothetical example
test.trioGxE Test of gene-environment interaction between a SNP and a continuous non-genetic covariate from case-parent trio data.
trioSim Simulate informative case-parent trios
trioGxE Generalized additive model estimation of gene-environment interaction using data from case-parent trios
plot.trioGxE Graphical display of gene-environment interaction between a SNP and a continuous non-genetic attribute in case-parent trio data
pirls.trio-internal Internal pirls.trio Functions
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Details

Type Package
Date 2013-04-02
LazyData true
License GPL-2
Packaged 2013-04-02 20:03:19 UTC; jshinb
NeedsCompilation no
Repository CRAN
Date/Publication 2013-04-03 01:39:24

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