Top Scoring Pairs for Microarray Classification
Description
These functions calculate the pair of genes that show the
maximum difference in ranking between two user specified
groups. This "top scoring pair" maximizes the average of
sensitivity and specificity over all rank based classifiers
using a pair of genes in the data set. The advantage of
classifying samples based on only the relative rank of a pair
of genes is (a) the classifiers are much simpler and often more
interpretable than more complicated classification schemes and
(b) if arrays can be classified using only a pair of genes, PCR
based tests could be used for classification of samples. See
the references for the tspcalc() function for references
regarding TSP classifiers.