rpact
Confirmatory Adaptive Clinical Trial Design, Simulation, and Analysis.
Functional Range
- Sample size and power calculation for
- means (continuous endpoint)
- rates (binary endpoint)
- survival trials with
- piecewise accrual time and intensity
- piecewise exponential survival time
- survival times that follow a Weibull distribution
- Fixed sample design and designs with interim analysis stages
- Simulation tool for means, rates, and survival data
- Assessment of adaptive sample size/event number recalculations
based on conditional power
- Assessment of treatment selection strategies in multi-arm trials
- Adaptive analysis of means, rates, and survival data
- Adaptive designs and analysis for multi-arm trials
- Adaptive analysis tools for enrichment design testing means, rates,
and hazard ratios
- Automatic boundary recalculations during the trial for analysis with
alpha spending approach, including under- and over-running
Installation
Install the latest CRAN release via
install.packages("rpact")
Documentation
The documentation is hosted at https://www.rpact.org
Vignettes
The vignettes are hosted at https://www.rpact.org/vignettes
The rpact user group
The rpact project has an active user group consisting of
decision-makers and users from the pharmaceutical industry and CROs, who
meet regularly and, e.g., discuss best practices.
We invite you to be part of the rpact user group: benefit from
know-how, shape open source development in Pharma!
Use on corporate computer systems
Please contact us to learn how to use
rpact
on FDA/GxP-compliant validated corporate computer systems and
how to get a copy of the formal validation documentation that is
customized and licensed for exclusive use by your company, e.g., to
fulfill regulatory requirements. The validation documentation contains
the personal access data for performing the installation qualification
with testPackage()
.
www.rpact.com/contact
About
- rpact is a comprehensive validated[1] R package for clinical
research which
- enables the design and analysis of confirmatory adaptive group
sequential designs
- is a powerful sample size calculator
- is a free of charge open-source software licensed under
LGPL-3
- particularly, implements the methods described in the recent
monograph by Wassmer and Brannath
(2016)
For more information please visit
www.rpact.org
- RPACT is a company which offers
- enterprise software development services
- technical support for the
rpact
package - consultancy and user training for clinical research using R
- validated software solutions and R package development for
clinical research
For more information please visit
www.rpact.com
- The rpact validation documentation is available exclusively for our
customers and supporting members. For more information visit
www.rpact.com/services/sla