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SAME (version 0.1.0)

Seamless Adaptive Multi-Arm Multi-Stage Enrichment

Description

Design a Bayesian seamless multi-arm biomarker-enriched phase II/III design with the survival endpoint with allowing sample size re-estimation. James M S Wason, Jean E Abraham, Richard D Baird, Ioannis Gournaris, Anne-Laure Vallier, James D Brenton, Helena M Earl, Adrian P Mander (2015) . Guosheng Yin, Nan Chen, J. Jack Lee (2018) . Ying Yuan, Beibei Guo, Mark Munsell, Karen Lu, Amir Jazaeri (2016) .

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Version

Install

install.packages('SAME')

Monthly Downloads

240

Version

0.1.0

License

GPL-2

Maintainer

Chengxue Zhong

Last Published

January 16th, 2023

Functions in SAME (0.1.0)

sim.trial.2

Function to simulate Bayesian seamless multi-arm biomarker-enriched phase II/III designs with user-defined cutoff points
find.cutoffs

Function to calibrate the cutoff points under null hypothesis
example.2

A Time-to-event dataset containing the time and other attributes of 643 patients.
conduct.phase3

Function to estimate the hazard ratios and other statistics of the selected subgroup
sim.trial

Function to simulate Bayesian seamless multi-arm biomarker-enriched phase II/III designs
conduct.phase2

Function to identify the most promising treatment-biomarker-linked subgroup
example.1

A Time-to-event dataset containing the time and other attributes of 643 patients.